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仅在头部和部状细胞癌中使用IMRT后的结果,通常与同时进行化疗和放射治疗一起管理

Marc Vincent N Barcelona¹, John Waldron², Brian O' Sullivan²

¹Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

|April 22, 2025

概括

强度调节辐射疗法 (IMRT) 单独是选择头皮状细胞癌 (HNSCC) 患者的可行的治疗方法. 这种方法对老年人或不适合使用西斯的个人来说是有前途的,但高级阶段需要进一步调查.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
头部和部癌症研究研究

背景情况:

同时化学放射治疗是许多头状状细胞癌 (HNSCC) 病例的标准.
仅强度调节辐射疗法 (IMRT) 已被作为一种替代治疗方式探索.
单独IMRT的患者选择标准和结果需要进一步阐明.

研究的目的:

为了评估IMRT单独治疗HNSCC患者的结果,通常与并发化疗或放射治疗一起进行治疗.
根据HPV状态和TNM-8分期来评估总体存活率 (OS).
为了确定影响HNSCC与IMRT单独治疗的OS的预后因素.

主要方法:

仅用IMRT (2005-2019) 治疗的HNSCC患者 (不包括T1-2 N0) 的回顾性分析.
用TNM-8标准重新分组患者,并根据HPV状态分层 (HPV+和HPV-).
用多变量分析 (MVA) 分析整体存活率 (OS),以确定预后因素.

主要成果:

总共有1083名患者 (460名HPV+,623名HPV-) 被纳入;化学疗法遗漏的原因各不相同 (年龄,虚弱,禁忌,偏好).
改变的分化方案通常用于IMRT输送.
五年OS率因HPV状态和阶段而有显著差异,HPV+阶段I单节点显示90%和HPV-阶段IVB显示13%.

结论:

改变的分离型IMRT单独是HPV+I期单节点HNSCC的有效选择.
它作为一个可接受的替代品,老年人/虚弱或西斯不合格的患者与特定的HPV+HNSCC阶段.
晚期HPV+ (T3-T4/N3) 或HPV-III/IV期HNSCC患者的生存状况不佳,需要研究替代治疗方法.

关键词:

西斯普拉丁不符合条件.头癌是头部和部的癌症.人类乳头瘤病毒人类乳头瘤病毒结果的结果.单独使用放射治疗.

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