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用于有效提取类抗生素的阴离子结合微孔聚合物:实验和DFT研究

Gui-Cheng Ge¹, Na Li¹, Ying-Jie Hao¹

¹College of Environmental Science and Engineering, Shandong Analysis and Test Center, Shandong International Joint Laboratory of Environmental and Biological Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, PR China.

Journal of chromatography. A

|April 22, 2025

概括

一种新的阴离子结合微孔聚合物 (iCMP) 能够在环境和食品样本中高度敏感地检测类抗生素 (QA). 这种方法提供了精确的微量分析,这对公共卫生和生态系统保护至关重要.

科学领域:

环境化学环境化学
分析化学分析化学
材料科学材料科学材料科学

背景情况:

昆类抗生素 (QA) 对生态系统和人类健康构成风险.
有效的质量保证监督需要敏感的分析方法.
现有的方法可能缺乏复杂矩阵的灵敏度或适用性.

研究的目的:

开发一种灵敏而准确的分析方法来检测类抗生素 (QA).
使用一种新型的阴离子结合微孔聚合物 (iCMP) 进行固相提取 (SPE).
为了验证复杂的环境和食品样本的方法.

主要方法:

通过后合成方法合成一个阴离子结合微孔聚合物 (iCMP).
使用iCMP开发固体相提取 (SPE) 方法.
将SPE方法与高性能液体染色学-协同质谱法 (HPLC-MS/MS) 的整合.
使用实验,DFT计算和材料表征进行吸附机制调查.

主要成果:

由于其双孔度,阴离子框架和π结合的骨干,iCMP表现出卓越的吸附能力和可重复性.
开发的HPLC-MS/MS方法实现了超低的检测极限 (水为0.0200-0.128 ng·L−1,肉为0.0250-0.105 ng·g−1).
该方法在复杂的样本矩阵中表现出良好的准确性 (70.9%-115%).

结论:

基于ICMP的SPE-HPLC-MS/MS方法为微量水平的QA分析提供了灵敏而准确的方法.
这一策略对于在各种环境和食品样本中监测质量评估是有效的.
这项研究为保护生态系统和公共卫生免受抗生素污染提供了有价值的工具.

关键词:

吸附机制是一种吸附机制.聚酸合微孔聚合物.昆类抗生素昆类抗生素固体相提取方法固体相提取方法水和肉的样本.

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