在患有重度抑郁症的患者中中断了半球间的功能和结构连接
Qianqian Li1, Li Qi2, Gu Zhang2
1Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230032, China; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei 230032, China; Anhui Provincial Institute of Translational Medicine, Hefei 230032, China.
Progress in neuro-psychopharmacology & biological psychiatry
|April 22, 2025
概括
大型抑郁症 (MDD) 与大脑连接功能受损有关. 语言的功能连接性减少和体结构损伤增加与抑郁症状相关.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
背景情况:
- 大型抑郁症 (MDD) 的特征是半球间合作被破坏.
- 在MDD患者的半球间通信中,结构性和功能性大脑变化之间的确切关系尚未完全理解.
研究的目的:
- 为了研究体 (CC) 中的声镜镜同位素连接性 (VMHC) 和辐射扩散性 (RD) 之间的关联.
- 检查这些连接措施与MDD患者的抑郁症状之间的联系.
主要方法:
- 利用休息状态功能性MRI (rs-fMRI) 和扩散性MRI (dMRI) 对60名MDD患者和38名健康对照 (HCs) 的研究.
- 在CC分区域评估半球间功能连接 (VMHC) 和结构完整性 (RD).
- 进行了群组比较,相关性分析和调解分析.
主要成果:
- 患有MDD的患者在双边后中心和语言转移中表现出减少的VMHC,并在CC子区域 (CC3,CC4,CC5) 增加了RD.
- 下面的舌环VMHC与抑郁症的严重程度有负相关性;CC4和CC5中增加的RD与抑郁症状有正相关性.
- 调解分析显示,语言膜VMHC完全调解了CC5 RD和抑郁症状之间的关系.
结论:
- 研究结果表明,MDD中乱的半球间协调,与症状严重程度相关的功能和结构障碍.
- 语言圈VMHC的调解作用突显了其在MDD病理生理学中的潜在意义.
- 结果提供了MDD中大脑功能和微观结构组织的综合观点.
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