变暖与土壤细菌中的五种药物类内的更多编码的抗微生物耐药性基因和转录有关:案例研究和合成
Melanie T Hacopian1, Alberto Barrón-Sandoval1, Adriana L Romero-Olivares2
1Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, California, USA.
Environmental microbiology
|April 22, 2025
概括
环境温度的上升与土壤细菌中抗微生物耐药性 (AMR) 基因的增加有关. 这项研究揭示了变暖和AMR基因的流行之间的联系,影响公共卫生.
科学领域:
- 环境微生物学环境微生物学
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 全球变暖对环境中的抗菌素耐药性 (AMR) 基因的影响是一个关键的公共卫生问题.
- 对环境温度和AMR基因流行率之间的关系的研究是有限的.
研究的目的:
- 研究土壤细菌基因组中最佳细菌生长温度和AMR基因含量之间的相关性.
- 分析气候变暖对自然生态系统中AMR基因转录的影响.
主要方法:
- 从BV-BRC数据库收集和分析已发表的土壤细菌基因组.
- 研究了最佳生长温度和编码AMR基因之间的关系.
- 分析了来自阿拉斯加北极森林变暖操纵实验的土壤转录组,以评估AMR基因转录.
主要成果:
- 在编码的AMR基因和土壤细菌的最佳生长温度之间发现了正相关性.
- 阿拉斯加生态系统的变暖导致八个药物类别的61个AMR基因相关转录的上调调节.
- 特定的药物类别,包括四环素和林科萨米德/麦克罗利德/链谱素,显示了与温度的最强的正相关性.
结论:
- 较高的环境温度与细菌基因组和转录组中抗微生物耐药性基因的患病率增加有关.
- 变暖显著影响自然生态系统中的AMR基因转录,对特定的抗生素类别有显著影响.
- 研究结果强调了气候变化对抗菌素耐药性的潜在公共卫生影响.
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