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Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Massively Parallel Reporter Assays in Cultured Mammalian Cells
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MPRAbase是一个大规模并行记者测试数据库.

Jingjing Zhao1, Fotis A Baltoumas2, Maxwell A Konnaris3

  • 1University of California San Francisco.

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|April 22, 2025
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概括
此摘要是机器生成的。

MPRAbase是大规模并行报告测试 (MPRA) 的新数据库. 它集中了来自130项实验的数据,涵盖了超过1700万个监管要素,使MPRA数据更容易获得研究.

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科学领域:

  • 基因组学和分子生物学
  • 生物信息学和计算生物学

背景情况:

  • 大规模并行报告员测定 (MPRA) 是评估基因调节活动的高通量技术.
  • 监管机构有多种应用,包括监管要素的发现和变异效应分析.
  • 缺乏MPRA结果的集中,全面的数据库,阻碍了数据的可访问性和整合.

研究的目的:

  • 开发MPRAbase,一个手动策划的数据库,巩固MPRA实验结果.
  • 提供一个用户友好的平台,在各种情况下访问和分析MPRA数据.

主要方法:

  • 从130个已发表的MPRA实验中手动整理数据.
  • 整合了关于 17,718,677 个测试元素, 35 种细胞类型和 4 种生物的信息.
  • 开发一个用于数据探索和下载的Web界面.

主要成果:

  • 目前MPRA数据库包含来自130个MPRA实验的数据.
  • 该数据库包含超过1770万个监管元素,分析了各种生物系统.
  • 为公众使用,已经建立了一个集中,可访问的Web界面.

结论:

  • MPRAbase解决了对MPRA数据的全面存储库的需求.
  • 该数据库有助于检查和下载监管要素活动数据.
  • MPRAbase将支持基因调节,变异分析和进化基因组学方面的进一步研究.