视觉皮层在眼睛打开之前自发活动的刻板的时空动力学
Luna Kettlewell1,2, Audrey Sederberg1,2,3, Gordon B Smith1,2,3
1Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455.
概括
视觉皮层发育中的自发活动形成模块化网络. 这些网络表现出复杂的,刻板的时空模式,这表明它们在改进未来的感官表现方面发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 功能性感官表现在成熟期间在视觉皮层中发展.
- 在眼睛打开之前,自发的神经活动形成模块化,远程网络.
- 这些网络的空间组织是已知的,但时间动态是研究不足的.
研究的目的:
- 描述视觉皮层发育中的自发网络活动的时间特征.
- 在功能视觉出现之前,研究早期皮质网络的时空动态.
主要方法:
- 用高时间分辨率 (50 Hz) 的广场成像 (GCaMP8m) 来记录小鹿视觉皮层的自发活动.
- 分析了数小时的成像数据,以捕捉毫秒时间尺度上的网络动态.
- 分析的重点是模块化结构,网络相关性,事件动态和时空模式预测.
主要成果:
- 自发活动显示了模块化的空间组织,具有分离的活跃域和长距离的相关性,约为几十毫秒.
- 大多数活动事件都有动态模式,模块在数百毫秒内移动.
- 复杂的,刻板的时空图案,而不仅仅是线性移动的波,被反复观察到.
- 特定的空间模式预测了未来的活动和扩展的时空轨迹.
结论:
- 早期视觉皮层的自发活动在快速时间尺度上具有刻板的时空结构.
- 这些动态模式可能在功能视觉表示的成熟和精细化中发挥关键作用.
- 了解这些早期网络动态,可以深入了解神经发育和可塑性.
相关概念视频
Mechanism of Ciliary Motion
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Cell-matrix's Response to Mechanical Forces
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
Mechanism of Ciliary Motion
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Muscles of the Eye
The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and rotating...
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and rotating...
Accessory Structures of the Eye
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
Anatomy of the Eyeball
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...


