通过与尼日利亚医疗保健工作者和为尼日利亚医疗保健工作者设计的代码干预措施来建立HPV疫苗的信心:试点集群随机对照试验的协议
Sibylle Herzig van Wees1, Ayobami Adebayo Bakare2,3, Kofoworola O Akinsola4
1Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden sibylle.hvw@ki.se.
BMJ open
|April 22, 2025
概括
这项试点研究评估了干预措施的可行性,以提高尼日利亚卫生保健工作者对人类乳头瘤病毒 (HPV) 疫苗的信心. 结果将为未来的大规模试验提供信息,以提高HPV疫苗接种率.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 人类乳头瘤病毒 (HPV) 疫苗的接种率在一些低收入地区较低,这是由于疫苗信心等障碍造成的.
- 尼日利亚的医疗保健工作者表现出对HPV疫苗的信心较低,受谣言和担忧的影响.
- 现有的干预措施来解决医疗保健工作者对疫苗的信心是有限的.
研究的目的:
- 评估试点集群随机对照试验 (cRCT) 的可行性,用于旨在提高卫生保健工作者对HPV疫苗的信心的干预措施.
- 评估在尼日利亚实施这些干预措施的可接受性和可行性.
主要方法:
- 在尼日利亚的吉加瓦州和奥约州,采用混合方法方法的3臂试点cRCT.
- 两个干预措施 (数字交付和HPV冠军) 与标准信息控制臂相比较.
- 12个集群 (初级医疗保健机构) 随机选择1:1:1;所有医疗保健工作者符合条件;主要结果是干预采用.
主要成果:
- 该研究旨在评估可行性和可接受性,干预的接受是试验可行性的主要衡量标准.
- 混合方法的数据收集包括终端调查,干预监测和定性访谈.
- 从相关的尼日利亚和瑞典委员会获得的伦理批准;在ISRCTN注册的试验.
结论:
- 这项试点cRCT将提供关键数据,以提高尼日利亚卫生保健工作者对HPV疫苗的信心,以提高干预措施的可行性和可接受性.
- 成功实施可以为更大的试验铺平道路,以解决低HPV疫苗接种率和预防子宫癌的问题.
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