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微血管抵抗储备的预后作用:系统性审查和元分析

Kyriakos Dimitriadis¹, Nikolaos Pyrpyris¹, Athanasios Sakalidis¹

¹First Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Hippokration General Hospital, 115 27 Athens, Greece.

Cardiovascular revascularization medicine : including molecular interventions

|April 22, 2025

概括

异常的微血管抵抗储备 (MRR) 显著增加了心血管死亡,主要不良事件,心肌梗塞和心力衰竭住院的风险. 这一新型指数显示了评估冠状动脉微血管功能障碍的预后价值.

科学领域:

心脏病学心脏病学
血管生物学血管生物学
医学诊断医学诊断医学诊断

背景情况:

冠状动脉微循环评估对于诊断心血管疾病至关重要.
微血管阻力储备 (MRR) 是一种新型指数,与冠状动脉流量储备 (CFR) 和微循环阻力指数 (IMR) 等传统指标相比,它具有优势.
了解MRR的预后意义对于其在冠状动脉微血管功能障碍中的临床应用至关重要.

研究的目的:

系统地审查和对MRR预后意义的现有研究进行元分析.
评估异常MRR与心血管不良结果之间的关联.
将MRR的预后值与其他微循环指数进行比较.

主要方法:

在MEDLINE/PubMed,科学网和Scopus进行了系统的文献搜索.
研究是根据PRISMA指南进行选择的.
对5项纳入研究的数据进行了随机效应元分析.

主要成果:

分析包括1605名患者,其中453人患有异常MRR.
异常MRR与较高的心血管死亡风险 (RR:4.88),主要心血管不良事件 (RR:2.37),心肌梗塞 (RR:1.93) 和心力衰竭住院 (RR:4.83) 的风险显著相关.
在异常MRR和未来的再血管化 (RR:1.29) 之间没有发现显著的关联.

结论:

MRR显示出显著的微循环特异性预后效应,对患者的生存率和不良心血管结果.
异常MRR是疑似冠状动脉微血管功能障碍患者预后不良的关键指标.
进一步的大规模随机研究是有必要的,以充分确定MRR的临床效用和预后影响.

关键词:

冠状动脉疾病是一种冠状动脉疾病.冠状动脉的流量储备.冠状动脉微血管功能障碍冠状动脉微血管功能障碍微循环是一种微循环.微血管阻力储备的微血管阻力

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