激光生成的铜纳米粒子涂层对模型冠状病毒和疹病毒的杀毒效果
Shahd Bakhet1, Rasa Mardosaitė1, Mohamed Ahmed Baba1
1Institute of Materials Science of Kaunas University of Technology, K. Baršausko Street 59, LT-51423 Kaunas, Lithuania.
ACS applied materials & interfaces
|April 22, 2025
概括
铜纳米粒子 (CuNPs) 创建有效的抗病毒涂层,使IBV和BoHV-1等病毒失活. 这些CuNP涂层中较高的铜含量增加了病毒失活,为抗击病毒性疾病提供了有希望的策略.
科学领域:
- 材料科学和纳米技术材料科学和纳米技术
- 病毒学和传染病学.
- 表面化学 表面化学
背景情况:
- 高效的抗病毒表面对于对抗COVID-19等病毒性流行病至关重要.
- 铜及其氧化物,包括铜纳米粒子 (CuNPs),具有强大的抗病毒特性.
- 为抗病毒材料开发具有成本效益和绿色合成方法至关重要.
研究的目的:
- 通过绿色激光切除方法合成和表征铜纳米粒子 (CuNPs).
- 开发和测试含有CuNPs的高通量喷涂表面,以检测其抗病毒功效.
- 评估CuNP涂层对禽传染性支气管炎病毒 (IBV) 和牛疹病毒 (BoHV-1) 的杀菌活性.
主要方法:
- 通过 Femtosecond 激光在水中消去 CuNPs 的绿色合成,用酸盐稳定.
- 使用拉曼光谱和X射线衍射对CuNPs进行表征,确认尺寸和组成.
- 在表面上使用聚乙醇作为粘合剂喷涂CuNPs的高通量喷涂,然后进行杀毒试验 (TCID50,实时PCR).
主要成果:
- 合成的CuNPs的平均尺寸为32nm,主要由金属铜和铜 (I) 氧化物组成.
- 基于CuNP的涂层对IBV (99.42100.00%的减少) 和BoHV-1 (98.6599.96%的减少) 显示出显著的抗病毒活性.
- 病毒失活与涂层中的铜含量正相关,对细胞培养物没有观察到毒性.
结论:
- 通过绿色合成和喷涂生产的基于CuNP的涂料是非常有效的抗病毒表面.
- 抗病毒疗效取决于铜度,导致病毒标位和核酸的显著减少.
- 这些发现凸显了CuNP涂层作为控制病毒感染的可行策略的潜力.
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