乳牛氧化压力的多omics分析确定了来自后肠的Phascolarctobacterium succinatutens表现出抗氧化活性
Duo Gao1, Yimin Zhuang1, Shuai Liu1
1State Key Laboratory of Animal Nutrition and Feeding, International Calf and Heifer Organization, College of Animal Science and Technology, China Agricultural University, Beijing, China.
NPJ biofilms and microbiomes
|April 22, 2025
概括
后肠细菌不平衡与牛的氧化应激 (OS) 有关. 引入特定的短链脂肪酸 (SCFA) 生产细菌,如P. succinatutens,有望减少OS并提高抗氧化能力.
科学领域:
- 微生物学 微生物学
- 动物科学动物科学
- 生物化学 生物化学
背景情况:
- 氧化应激 (OS) 源于宿主氧化-抗氧化过程的不平衡.
- 后肠微生物群的改变经常与OS有关,但潜在的机制尚不清楚.
研究的目的:
- 研究微生物和代谢因素,将后肠微生物群与产后奶牛的OS联系起来.
- 评估特定细菌在缓解OS方面的潜力.
主要方法:
- 多omics方法包括16S rRNA基因测序,元基因组分析和81只产后霍尔斯坦牛的非目标代谢学.
- 根据氧化应激指数 (OSi) 分为高氧化应激 (HOS) 和低氧化应激 (LOS) 的分层.
- 在体内研究中,向C57BL/6J小鼠注射Phascolarctobacterium succinatutens (P. succinatutens),以评估OS缓解作用.
主要成果:
- 洛斯奶牛表现出更高水平的金氨酸,甲基-5-氧基氨酸和5-基-3-酸.
- 洛斯奶牛的短链脂肪酸 (SCFA) 生产细菌 (例如,P. succinatutens) 的丰富性增加,与OSI负相关.
- 在小鼠中,口服P. succinatutens显著增强了抗氧化能力,减少了OS标记物,并激活了Nrf2-Keap1通路.
结论:
- 系统性托代谢和受后肠微生物群影响的SCFA生产障碍与OS发展有关.
- 调节后肠微生物群,特别是通过引入SCFA产生细菌,是对抗OS的有希望的战略.
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