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预测慢性乙型肝炎 (CHB) 实现功能治愈后的复发,使用基线HBsAg和治疗结束时的HBsAb水平

Lianxiu Han¹, Zilong Wang¹, Luyang Kang¹

¹Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Scientific reports

|April 22, 2025

概括

慢性乙型肝炎 (CHB) 患者在初始乙型肝炎表面抗原 (HBsAg) 低于100 IU/mL,治疗结束时乙型肝炎表面抗体 (HBsAb) 超过500 mIU/mL时,实现功能治愈的复发率较低.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
免疫学免疫学免疫学

背景情况:

慢性乙型肝炎 (CHB) 管理的目标是功能治愈,但治疗后的复发停止是一个问题.
缺乏用于预测CHB功能治愈后复发的标准化标志物.
乙型肝炎表面抗原 (HBsAg) 和抗体 (HBsAb) 水平是CHB复发的潜在指标.

研究的目的:

为了研究基线HBsAg和治疗结束时HBsAb水平与实现功能治愈后CHB复发之间的关联.
为了确定CHB患者复发的预测因素.

主要方法:

一个多中心,对136名CHB患者进行了回顾性研究,这些患者实现了功能治愈.
对基线HBsAg和治疗结束HBsAb水平的分析,与48周随访期间的复发相关.
统计方法包括单变量,多因素逻辑回归和卡普兰-梅尔生存分析.

主要成果:

较高的基线HBsAg水平 (≥100 IU/mL) 与增加的CHB复发明显相关 (P=0.038).
治疗结束时较低的HBsAb水平 (<500mIU/mL) 与更高的复发率 (P=0.014) 有关.
基线HBsAg≤100 IU/mL和治疗结束HBsAb≥500 mIU/mL的患者呈现低累积复发率 (分别为3.8%和12.2%).

结论:

基线HBsAg度≥100 IU/mL是CHB复发的危险因素.
治疗结束时HBsAb度≥500mIU/mL是预防CHB复发的保护因素.
特定的HBsAg和HBsAb值可以帮助识别功能治愈的CHB患者,其复发风险较低.

关键词:

这就是HBsAbAb.这就是HBsAg.卡普兰·梅耶尔 (Kaplan 梅耶尔) 是一个后勤回归分析的分析这个名字是名ogramogram.

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