艾滋病患者体质指数和代谢综合征之间的独特关系
Shiqi Sun1, Shengming Zhou2, Qi Huang3
1Department of Clinical Laboratory, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, 430072, China.
代谢综合征 (MS) 风险在中国艾滋病毒/艾滋病 (PLWHA) 感染者中较高,即使在较低的身体质量指数 (BMI) 水平. 20公斤/平方米的BMI是预测这一群体中多发性硬化症的关键值.
科学领域:
- 代谢健康 代谢健康
- 流行病学 流行病学
- 艾滋病毒/艾滋病研究研究
背景情况:
- 代谢综合征 (MS) 对艾滋病毒/艾滋病 (PLWHA) 感染者构成重大健康风险.
- 在PLWHA中,特别是在中国,对MS的体重指数 (BMI) 的预测值尚不清楚.
- 了解特定人群的代谢风险模式对于有效管理至关重要.
研究的目的:
- 在住院的中国艾滋病患者中调查BMI和MS之间的关联.
- 为了确定特定人群的代谢风险模式和偏离一般人群基准的偏差.
- 确定临床相关的BMI值,以预测该队列中的MS.
主要方法:
- 招募482名住院艾滋病患者,按BMI (体重不足,正常,超重/肥胖) 分类.
- 使用中国糖尿病学会 (CDS) 标准诊断MS.
- 统计分析包括相关性,多变量逻辑回归和ROC曲线分析.
主要成果:
- 综合性多发性硬化症的总体患病率为8.92%,超重/肥胖群体的患病率 (24.1%) 与正常体重 (6.8%) 相比显著更高.
- 体重指数与MS诊断有很强的相关性 (r=0.42) 和组件负担 (r=0.38).
- 20公斤/平方米的BMI截止值被认为是MS的预测值 (AUC=0.79),远低于一般人群的值.
结论:
- 在中国PLWHA中存在着明显的BMI-MS关系,在BMI值较低时发生代谢并发症.
- 在这个人群中,建议BMI值为20kg/m2用于MS风险分层.
- 针对HIV的特定代谢查和早期的BMI指导干预措施对于减轻PLWHA中心血管风险至关重要.
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