糖尿病诊断时的年龄与糖尿病视网膜病变的发展和进展之间的关联
Hui Li1, Bin Wang2, Chunlin Liu3
1Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400000, China.
Scientific reports
|April 22, 2025
概括
年轻时被诊断患有糖尿病意味着糖尿病视网膜病变 (DR) 的风险更高. 糖尿病诊断时的年龄较大提供了对DR发展和进展的保护. 早期查对于年轻发病的糖尿病患者至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
- 糖尿病诊断时的年龄 (ADD) 是DR的潜在风险因素.
- 了解ADD和DR之间的关系对于患者管理至关重要.
研究的目的:
- 研究糖尿病诊断 (ADD) 时的年龄与糖尿病视网膜病变 (DR) 的发展和进展之间的关联.
- 为了确定年轻的ADD是否会增加DR风险或严重程度.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据 (n=877).
- 门德尔的随机化 (MR) 分析.
- 使用了回归模型,倾向得分匹配,通用添加模型 (GAM) 和随机森林算法.
主要成果:
- 较年轻的ADD与较高的DR患病率 (P<0.001) 有显著的关联.
- 在ADD和DR患病率 (OR=0.96,P<0.001) 之间发现了不良关联,并得到了MR (OR=0.42,P=0.003) 的支持.
- 年轻的ADD与DR严重程度的增加相关,并且在24岁左右确定了DR发生概率的峰值.
结论:
- 糖尿病诊断时的年龄较大表明对DR的发展和进展有保护作用.
- 这些发现强调了在年轻时被诊断患有糖尿病的人群中需要保持警的监测和频繁的DR查.
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
475
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
475
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Psychoneuroimmunology: Diabetes and Cancer
19
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
19
Pathophysiology of Diabetes
807
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
807
Diabetes Mellitus: Overview and Type I Subtype
2.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.3K
Photoreceptors and Visual Pathways
5.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.5K


