空气污染和饮食模式对慢性阻塞性肺病风险的联合影响
Enlin Ye1,2, Zihan Xu1,2, Xuefei Hou1,2
1Clinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Scientific reports
|April 22, 2025
概括
饮食不良和空气污染增加了慢性阻塞性肺病 (COPD) 的风险. 改善饮食可能有助于抵消空气污染.
科学领域:
- 环境健康 环境健康
- 营养流行病学 营养流行病学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 饮食模式和空气污染是已知的慢性阻塞性肺病 (COPD) 的危险因素.
- 饮食和空气污染对COPD发病率的综合影响需要进一步研究.
研究的目的:
- 研究饮食模式和空气污染对COPD风险的独立和联合影响.
- 评估饮食干预措施在减轻空气污染对COPD的不利影响方面的潜力.
主要方法:
- 利用了314,226名英国生物库参与者的前队列 (2006-2010年).
- 基于特定食物的摄入量和暴露于PM2.5,PM2.5-10,NO2和NOx的结构性饮食和空气污染得分.
- 采用Cox比例危险模型和相互作用分析来评估独立和联合效应,在培训和验证套件上得到验证.
主要成果:
- 较低的饮食模式得分与明显更高的COPD风险相关 (HRs 1.11-1.31).
- 对空气污染的暴露增加与COPD风险增加相关 (HRs为1.06-1.13,对于较高的五分位数).
- 发现了饮食和空气污染对COPD风险的重大联合影响的有限证据.
结论:
- 低于最佳的饮食模式和空气污染都会独立增加COPD风险.
- 可修改的饮食干预措施显示出抵消空气污染对COPD发展的有害影响的潜力.
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