快速调节肠道微生物群的组成,通过大脑下丘脑电路在小鼠
Míriam Toledo1, Sara Martínez-Martínez2, Matthias Van Hul3,4
1Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Nature metabolism
|April 22, 2025
概括
下丘脑可以通过神经通路快速改变肠道微生物群的组成. 这种大脑-肠轴通信影响能量平衡,并且可能因肥胖而受到干扰.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢过程中的代谢.
背景情况:
- 肠道微生物群通过代谢物影响大脑功能,包括能量平衡.
- 像勒和格林这样的激素向大脑,特别是下丘脑,信号能量状态.
- 下丘脑对肠道微生物群组成的影响尚不清楚.
研究的目的:
- 为了研究下丘脑能否调节肠道微生物群的组成.
- 探索关于微生物群的脑肠轴通信的时间尺度和机制.
主要方法:
- 在雄性小鼠中,对下丘脑神经元 (POMC和AgRP) 的化学遗传操纵.
- 中心给药莱普或格林.
- 16S rRNA基因测序用于肠道微生物群分析.
- 十二指肠组织的转录组分析.
主要成果:
- 脑下垂体干预迅速 (2-4小时) 改变了肠道微生物群的组成.
- 这些变化与十二指甲神经元/突触通路的重新配置和交感音调的增加相关.
- 饮食诱导的肥胖减少了勒普丁对微生物群和同情激活的影响.
结论:
- 一个新的大脑-肠轴在快速的时间尺度上敏调节肠道微生物群的组成.
- 这个轴在每餐调整和全身能量平衡中起作用.
- 肥胖可能会损害这种脑肠沟通通路径.
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