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Updated: Jun 16, 2025

Adult and Embryonic Skeletal Muscle Microexplant Culture and Isolation of Skeletal Muscle Stem Cells
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用BML-260调节酸酶DUSP22,通过Akt独立的JNK-FOXO3a抑制改善了骨肌肉的消耗

Sang-Hoon Lee1, Hyun-Jun Kim1, Seon-Wook Kim1

  • 1New Drug Targets Laboratory, Department of Life Sciences, College of Life Sciences and Medical Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.

EMBO molecular medicine
|April 22, 2025
PubMed
概括

双特异性酸酶22 (DUSP22) 在肌肉消耗条件上升调节,如肉症. 用BML-260向DUSP22,通过抑制JNK-FOXO3a通路来预防肌肉缩,提供了一个潜在的治疗策略.

关键词:
在BML-260中使用.DUSP2222 在美国这就是FOXO3a.肌纤维缩症 肌纤维缩症骨肌肉的消耗 骨肌肉的消耗

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