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性结肠炎及其相关的肠内外肠道并发症的综合管理,使用多功能胰岛素凝复合体
Silong Wu1, Yaoyu Hu2, Zhenchao Tao3,4
1School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.
结合普鲁士蓝色纳米酶和纳托金酶的新凝通过减少氧化应激,炎症和微血栓形成,有效治疗性结肠炎,同时改善肠道微生物群平衡和相关焦虑.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 胃肠病学 胃肠病学
背景情况:
- 性结肠炎 (UC) 的发病包括活性氧物种 (ROS) 和肠道失调.
- UC并发症包括肠道微血栓和心理症状,如焦虑和抑郁.
研究的目的:
- 开发和评估一种用于治疗UC的多功能胰岛素凝 (PB/NKase@Inulin).
- 解决UC的肠道和肠外表现.
主要方法:
- 一种含有普鲁士蓝色纳米酶 (PB NZs) 和纳托金酶 (NKase) 的胰岛素凝的配方.
- 在甲 (DSS) 诱导的UC小鼠模型中口服.
- 评估ROS清除,抗炎作用,血栓溶解,肠道微生物群调节和行为变化.
主要成果:
- PB/NKase@胰岛素凝在炎症的结肠部位表现出长时间的保留.
- 凝有效地清除了ROS,减少了炎症,并抑制了/解了微血栓.
- 通过肠道微生物群-肠道-大脑轴观察到肠道微生物群平衡的调节和焦虑和抑郁症状的缓解.
结论:
- PB/NKase@Inulin凝为DSS诱导的UC提供了一个全面的治疗策略.
- 这种方法针对氧化应激,炎症,微血栓和肠-大脑轴失调.
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