甲状腺疾病干眼患者的临床特征:一个横截面研究
Yiteng Lu1, Xichen Wan1, Han Ye1
1Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.
BMC ophthalmology
|April 23, 2025
概括
患有甲状腺疾病的干眼病患者的非侵入性眼破裂时间 (NIBUT) 较短,梅博姆腺脱落率较高. 这些发现,特别是抗TPO和抗Tg抗体的升高,表明NIBUT和MG退学评估可以预测甲状腺问题.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 干眼病 (DED) 是一种多因素影响眼表面健康的疾病.
- 甲状腺疾病,特别是自身免疫性甲状腺疾病,已知有眼部表现.
- DED和甲状腺功能障碍之间的特定临床关联需要进一步描述.
研究的目的:
- 研究甲状腺疾病患者干眼病的临床特征.
- 探索干眼疾病的症状和迹象与甲状腺功能之间的关系.
- 在DED患者中识别甲状腺疾病的潜在生物标志物.
主要方法:
- 对99名接受甲状腺功能查的DED患者进行了回顾性的横截面图表审查.
- 评估干眼症状,包括角膜光染色 (CFS),希尔默1测试 (S1T),眼半径高度 (TMH),非侵入性眼破裂时间 (NIBUT-first和NIBUT-avg),以及梅博米腺 (MG) 脱落率.
- 眼部发现和甲状腺功能测试之间的相关性分析,包括抗甲状腺过氧化酶抗体 (Anti-TPO) 和抗甲状腺球蛋白抗体 (Anti-Tg).
主要成果:
- 与没有甲状腺疾病的患者相比,患有甲状腺疾病的DED患者的NIBUT (NIBUT-first和NIBUT-avg) 显著缩短,MG学率更高.
- 较高的抗TPO和抗Tg水平与降低的NIBUT和增加的MG退学有很强的相关性.
- 接收器操作特征 (ROC) 曲线分析表明,NIBUT和MG放弃率,单独和组合,显示出预测甲状腺疾病的良好诊断潜力 (AUC高达0.841).
结论:
- 减少NIBUT和增加MG放弃是甲状腺疾病的DED患者的显著临床发现.
- 升高的抗TPO和抗Tg抗体与这些特定的眼睛表面变化有关.
- 结合NIBUT和MG脱学率的评估,可以作为一种有价值的预测生物标志物,用于识别DED患者的甲状腺功能障碍.
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