暴露于挥发性有机化合物与生物衰老的关联:一个横截面研究
XinYu Shi1, YiNi Wang1, Fei Yang1
1Department of Hygienic Toxicology, School of Public Health, Harbin Medical University, 157 Baojian Road, NanGang District, Harbin, 150081, Heilongjiang Province, PR China.
BMC public health
|April 23, 2025
概括
暴露于挥发性有机化合物 (VOC) 与生物衰老有关. 像吸烟和体力活动低等日常行为可以增加对VOCs的易感性,影响健康和衰老.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 毒理学 毒理学 毒理学
背景情况:
- 挥发性有机化合物 (VOC) 与健康问题有关,但它们对生物衰老的影响尚不清楚.
- 了解VOCs在衰老中的作用对于公众健康至关重要.
- 这项研究研究了VOC暴露与生物衰老之间的关联.
研究的目的:
- 为了确定暴露于挥发性有机化合物 (VOC) 是否与加速的生物衰老有关.
- 为了识别可能影响衰老的特定VOC和混合物.
- 探索日常行为如何改变VOC暴露和生物衰老之间的关系.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2011-2016) 的分析,来自3,205名参与者.
- 使用PhenoAge加速评估的生物衰老,从像白蛋白和性酸酶这样的指标计算出来.
- 权重多变量逻辑回归和权重量积回归 (WQS) 用于分析单个和混合的VOC暴露.
主要成果:
- 个体VOC暴露与生物衰老有显著的关联.
- 混合的VOC暴露显示出与生物衰老的积极关联 (OR = 1.523,P < 0.001).
- 吸烟,饮酒和较低的体力活动水平加剧了VOCs对衰老的影响,特别是在吸烟者中.
结论:
- 易挥发性有机化合物 (VOC) 暴露与加速的生物衰老有关.
- 每天的行为,包括吸烟,饮酒和身体活动,调节对VOCs的敏感性.
- 结果提供了关于减轻衰老过程和通过减少VOC暴露来改善健康的见解.
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