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在老年中国人中发生疹和负担:系统性审查和元分析

Bingbing Zheng1, Dapeng Yin2, Yifan Geng1

  • 1School of Public Health, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, 571199, Hainan Province, China.

BMC public health
|April 23, 2025
PubMed
概括

在中国,老年人中,带状疹 (HZ) 发病率和医疗费用正在上升. 这一趋势凸显了包括疫苗接种在内的公共卫生战略的必要性,以减轻日益增长的HZ负担.

关键词:
华人中文 华人中文是什么意思医疗保健成本 医疗保健成本这是一种疹 (herpes zoster).影响影响 影响 影响系统性审查 系统性审查

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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