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苏格兰不同年龄组的女性的分子亚型的乳腺癌特异性生存率

Ines Mesa-Eguiagaray¹, Sarah H Wild², Linda J Williams²

¹Usher Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK. ieguiaga@ed.ac.uk.

Breast cancer research : BCR

|April 23, 2025

概括

患有乳腺癌 (BC) 的老年女性 (70岁以上) 面临更高的BC特异性死亡率,特别是光线亚型. 年龄影响BC生存,但瘤特征和治疗是非光线亚型的关键.

科学领域:

在瘤学瘤学.
流行病学流行病学
生物统计学生物统计学

背景情况:

乳腺癌 (BC) 的预后受到患者年龄和瘤分子亚型的显著影响.
了解年龄和BC亚型之间的相互作用对于提高生存率至关重要.

研究的目的:

调查年龄和分子亚型对大规模苏格兰队列乳腺癌特定存活率的影响.
在不同乳腺癌分子亚型中识别与年龄相关的死亡风险.

主要方法:

分析了71,784名在苏格兰被诊断患有侵入性乳腺癌的妇女 (1997-2016) 的数据.
利用考克斯模型估计BC特定死亡的危险比率 (HR) 跨年龄组,参考50-69岁的女性.
员工累积发病率函数用于考虑非BC死亡率的竞争风险.

主要成果:

与50-69岁的年龄组相比,70岁及以上的妇女在光线A,光线B和三阴性乳腺癌 (TNBC) 亚型中表现出较高的BC特异性死亡率.
年轻女性 (<50岁) 只有在光线A亚型中,BC死亡风险降低.
竞争性风险分析显示,老年女性 (70岁以上) 的非BC死亡累积发病率较高,特别是那些具有荷尔蒙阳性亚型的女性.
阶段,治疗和分子亚型成为所有年龄组BC特定死亡率的最重要的预后因素.

结论:

年龄是乳腺癌特异性死亡率的重要决定因素,特别是在光线亚型中.
对于非光学亚型,瘤特征和治疗方式是主要的预后指标.
需要进一步的研究来探索BC死亡率的额外标志物,特别是在70岁以上的人群中,这代表了BC死亡的很大一部分.

关键词:

年龄年龄年龄年龄年龄年龄乳腺癌是什么? 乳腺癌是什么?预测预后预测预测副类型副类型副类型

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