相关实验视频

Updated: May 10, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

嵌合式抗原受体-T细胞治疗对于内分泌癌症的潜力

Ruonan Yu¹, Xiaoyu Ji¹, Ping Zhang¹

¹Department of Thyroid Surgery, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.

World journal of surgical oncology

|April 23, 2025

概括

化学抗原受体 (CAR) T细胞疗法在内分泌癌症治疗方面表现有前途,尽管存在挑战. 本综述探讨了CAR-T细胞的生成,潜在的应用,抗原,限制和内分泌癌症的策略.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

内分泌癌是罕见的,异质的,由于荷尔蒙合成,难以治疗.
需要系统性治疗,比如嵌合抗原受体 (CAR) T细胞疗法.

研究的目的:

审查用于内分泌癌的CAR-T细胞疗法.
为了确定这种方法的抗原,挑战和策略.

主要方法:

关于CAR-T细胞生成和内分泌癌症中的应用的文献综述.
分析潜在的目标和治疗挑战.
讨论克服局限性的策略.

主要成果:

卡特-T细胞疗法具有潜力,但在内分泌癌症中面临并发症.
确定了内分泌癌症CAR-T标的关键抗原.
挑战包括抗原异质性和潜在的毒性.

结论:

卡特-T细胞疗法为内分泌癌症治疗提供了一个有前途的途径.
克服挑战对于成功的临床翻译至关重要.
需要进一步的研究来优化对内分泌恶性瘤的CAR-T细胞疗法.

关键词:

抗原是针对抗原的目标.在CAR-T细胞中.内分泌癌症是什么?内分泌癌症是什么?免疫治疗是一种免疫疗法.甲状腺是什么?甲状腺是什么?

更多相关视频

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

Published on: November 12, 2019

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

Published on: February 27, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...