相关实验视频

Updated: May 10, 2025

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

17.2K

系统性炎症和无情的反应,以一个炎症的挑战在成年人患有严重抑郁症:一个随机对照试验

Jonathan Savitz1, Leandra K Figueroa-Hall1, T Kent Teague1

  • 1Laureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).

The American journal of psychiatry
|April 23, 2025
PubMed
概括

患有高C反应蛋白 (CRP) 的重度抑郁症患者在脂多糖 (LPS) 挑战后表现出增加的无情感和IL-6. 这表明系统性炎症将抑郁的个体引入炎症刺激,影响无症症状.

关键词:
抑郁症 抑郁症 抑郁症炎症 炎症是一种炎症.严重的抑郁症 严重的抑郁症

更多相关视频

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

21.8K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.3K

相关概念视频

Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
50
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
189
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
16
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.6K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
17
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
45