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相关概念视频

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Tagging and Fusion Proteins

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Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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Prodrugs

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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
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Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

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Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
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Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
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Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
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基化技术:解决问题,向前迈进

Dmitri Simberg1,2, Yechezkel Barenholz3, Steve R Roffler4,5

  • 1Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences and Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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概括
此摘要是机器生成的。

聚乙烯甘醇 (PEG) 化增强了药物输送,但新出现的抗PEG抗体引发了安全问题. 需要进一步的研究,以了解免疫反应,并探索PEG替代品的未来药物.

关键词:
抗聚合物 (乙烯基醇) 抗体.基化治疗药物PEGylated治疗药物互补系统是互补的系统.免疫性 免疫性 免疫性纳米医药是一种纳米医药.

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科学领域:

  • 生物制药的发展.
  • 药物输送系统是药物输送系统.
  • 免疫学 免疫学 免疫学

背景情况:

  • 聚乙烯甘醇 (PEG) 基化是现代医学的关键技术,增强了生物制剂,疫苗和纳米药物的特性.
  • 目前有超过30种PEGylated产品在临床上使用,改善了药物稳定性,药理动力学和生物分布.
  • 尽管一般的安全性,但对抗PEG抗体及其对治疗疗效和免疫反应的潜在影响的担忧正在增加.

研究的目的:

  • 概述围绕抗PEG抗体及其对PEG化药物的影响的担忧.
  • 鼓励研究抗PEG抗体在过敏反应中的作用.
  • 讨论PEG的替代品,并提出推进PEGylation技术的战略.

主要方法:

  • 文献综述和关于PEGylation和抗PEG抗体的现有证据的综合.
  • 分析抗PEG抗体对治疗疗效和免疫反应的影响.
  • 对PEGylation的替代策略的探索.

主要成果:

  • 越来越多的证据表明,抗PEG抗体可以影响PEG化药物的性能.
  • 关于与抗PEG抗体相关的补充激活和过敏反应存在担忧.
  • 由于这些新出现的免疫学问题,PEGylation技术的长期可行性受到质疑.

结论:

  • 解决抗PEG抗体的影响对于PEGylation的持续成功至关重要.
  • 需要进一步研究PEGylation的免疫后果.
  • 探索和开发PEG替代品对于未来的药物设计和患者安全至关重要.