在接受生长激素治疗的儿童和青少年中发生的面变化:系统性审查
Raul Borges Nascimento1, Suelly Maria Mendes Ribeiro2, Nathalia Carolina Fernandes Fagundes2
1Faculty of Dentistry, Federal University of Pará, Belém, Brazil.
Orthodontics & craniofacial research
|April 23, 2025
概括
在患有GH缺乏或异常矮身 (ISS) 的儿童中,生长激素 (GH) 治疗显示下尺寸的增加很小,在临床上无关紧要. 需要更多的长期研究来证实对面生长的影响.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 面生物学 面生物学
- 系统审查方法论 系统审查方法论
背景情况:
- 增长激素 (GH) 治疗用于患有GH缺乏或异常矮身 (ISS) 的儿童.
- 了解GH治疗对面发育的影响对于监测治疗结果至关重要.
- 之前的研究已经产生了不同的结果,关于在GH治疗期间的头骨面部变化.
研究的目的:
- 在患有GH缺乏或ISS的儿科群体中,系统地审查面变化和GH治疗之间的关联.
- 综合关于GH治疗对脑电测量测量和牙年龄的影响的证据.
- 评估包含的研究的偏见风险和证据确定性.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在七个数据库中进行电子搜索,没有年份或语言限制.
- 包括接受GH治疗的儿童/青少年面变化的研究;使用JBI,RoB 2.0和GRADE工具评估的偏差风险和证据确定性.
主要成果:
- 从4494个已识别的引用中,有7项研究符合资格标准.
- 增生激素治疗显示下大小的微小,临床上无意义的增加.
- 在立即和延迟治疗之间,在上下尺寸上没有发现显著的差异.
- 在所有结果中观察到偏差风险低,证据确定性低.
结论:
- GH治疗可能会导致下和上尺寸略微增加,但没有显著的不良健康影响.
- 目前的证据表明,对面生长的临床影响很小.
- 需要进一步进行长期随访的受控干预研究,以确定准确的建议.
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