加拿大的人类乳头瘤病毒 (HPV) 相关的口腔癌:一个多中心的回顾性队列研究
Voica Racovitan1, Elizabeth Goodman2, Winson Y Cheung3
1Global Marketing HPV Strategy, Merck & Co. Inc ., North Wales, PA, USA.
Human vaccines & immunotherapeutics
|April 23, 2025
概括
在加拿大,口腔人类乳头瘤病毒 (HPV) 感染是口腔癌 (OPC) 的驱动因素. 这项研究发现,大多数OPC病例是HPV阳性,特别是在男性,年轻人和非吸烟者中,支持HPV疫苗接种.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 口腔人类乳头瘤病毒 (HPV) 感染是口腔癌 (OPC) 的重要危险因素.
- 在加拿大男性中,OPC是主要的HPV相关癌症.
- 自2015年以来,在加拿大OPC病例中,常规的p16测试是检测HPV状态的标准.
研究的目的:
- 为了确定加拿大OPC的HPV归因分数.
- 为了分析与HPV相关的OPC趋势,使用p16作为替代标记物.
- 确定与HPV相关的OPC相关的人口和生活方式因素.
主要方法:
- 追溯地查看平细胞OPC病例 (≥18年) 诊断在2016-2020年间的病例.
- 包括来自加拿大四个主要医院的区域瘤中心的数据.
- 利用p16瘤标志物状态作为HPV阳性的替代品.
主要成果:
- 发现了1154例OPC病例;80.6%是p16阳性 (与HPV相关).
- 与HPV相关的OPC在男性 (84.0%),年轻患者 (平均年龄61.6岁) 和从未吸烟者 (92.3%) 中更为普遍.
- 通过对男性性别,年龄较小,瘤较低的阶段和非吸烟者的逻辑回归证实了显著的关联.
结论:
- 这项研究证实了加拿大OPC的高HPV归因分数.
- 与HPV相关的OPC不成比例地影响男性,年轻人以及从未吸烟的人.
- 研究结果支持性别中立的HPV疫苗接种作为预防头癌的关键策略.
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