相关实验视频

Updated: Jul 1, 2026

Morphometric Analyses of Retinal Sections
14:33

Morphometric Analyses of Retinal Sections

Published on: February 19, 2012

10.2K

布罗西明B和双相剂量反应:对霍尔梅西斯和视网膜神经保护的洞察

Susanne Suely Santos Fonseca1,2, Natacha M S Port's3, Gisele Priscila Soares Aguiar3

  • 1Institute of Technology, Federal University of Pará, Belém, Pará, Brazil.

Frontiers in pharmacology
|April 23, 2025
PubMed
概括

布罗西明B是一种天然的黄类化合物,在低剂量时对视网膜细胞产生有益作用,但在较高度时有毒. 通过计算建模证实了这种抑制效应,这表明治疗与氧化压力相关的视网膜损伤的潜力.

关键词:
兄弟姐妹们在一起.抗氧化剂是一种抗氧化剂.霍尔梅西斯的存在自然产品是自然产品的产品.神经保护神经保护氧化应激是一种氧化应激.视网膜细胞是视网膜细胞.

更多相关视频

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions07:49

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Published on: September 17, 2014

11.5K
Simultaneous ex vivo Functional Testing of Two Retinas by in vivo Electroretinogram System09:16

Simultaneous ex vivo Functional Testing of Two Retinas by in vivo Electroretinogram System

Published on: May 6, 2015

9.1K

相关概念视频

Dose-Response Relationship: Overview01:03

Dose-Response Relationship: Overview

Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and β2-adrenergic receptors...
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
Dose Response Curve: Conventional Versus Nonmonotonic01:21

Dose Response Curve: Conventional Versus Nonmonotonic

The correlation between a drug's dosage and its impact on a biological system is a cornerstone of pharmacology and toxicology. Conventional dose–response curves, which include graded and quantal relationships, are key to this understanding. Graded dose–response curves depict the spectrum of a biological reaction to different doses within an individual, indicating that as the drug dosage increases, so does the intensity of the response. On the other hand, quantal dose–response relationships...