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肠道微生物群的饮食指数与慢性病之间的关联:美国人口的横截面研究
Xuanzhen Zhou1, Chengxiao Jiang2, Baiyang Song1
1Department of Urology, Ningbo Clinical Research Center for Urological Disease, Zhejiang Engineering Research Center of Innovative technologies and diagnostic and therapeutic equipment for urinary system diseases, The First Affiliated Hospital of Ningbo University, Ningbo, China.
较高的肠道微生物群 (DI-GM) 饮食指数得分,强调有益的食物,与较低的慢性病 (CKD) 患病率和更好的结果有关. 这凸显了饮食在通过肠道微生物群调节来管理CKD的重要性.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 腎臟病學 (nephrology) 是一種神經病學.
背景情况:
- 饮食显著影响肠道微生物群的组成和功能.
- 肠道微生物群失调与慢性病 (CKD) 的进展有关.
- 一个新的肠道微生物群饮食指数 (DI-GM) 已被提出,以量化与肠道健康相关的饮食质量.
研究的目的:
- 调查DI-GM与CKD患病率之间的关联.
- 检查DI-GM与CKD预后之间的关系.
- 确定导致这些关联的特定饮食成分.
主要方法:
- 从美国国家健康和营养检查调查 (2007-2020) 中对28512名参与者的横截面分析.
- 基于14个有益和不利的饮食成分计算DI-GM分数.
- 统计建模包括加权线性回归,后勤回归和受限立方线分析.
主要成果:
- 更高的DI-GM得分与降低CKD患病率 (OR=0.967) 和更好的预后 (OR=0.877) 有关.
- 有益的DI-GM成分与CKD风险有显著的反向关联 (OR=0.928).
- 咖啡,纤维和全谷物被确定为对CKD流行和预后的关键饮食贡献者.
结论:
- 较高的DI-GM,反映了有益食物的消费,与较低的CKD患病率和改善的预后有关.
- 促进健康肠道微生物群的饮食模式可能对管理和预防CKD至关重要.
- 针对咖啡,纤维和全谷物等特定的饮食成分可能有利于CKD管理.
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