预测幻觉药物持续感知障碍和思维障碍症状在迷幻药使用后的预测
Katie Zhou1, David de Wied1, Robin L Carhart-Harris1,2
1Centre for Psychedelic Research, Department of Brain Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
PNAS nexus
|April 23, 2025
概括
迷幻药的使用可能会减少妄想,但不会改变魔法思维. 类似于幻觉持续感知障碍 (HPPD) 的症状影响了30%以上的使用者,但通常是亚临床的.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 越来越多的人对精神病治疗的迷幻药物感兴趣.
- 需要了解不同人群中的副作用风险.
- 在自然环境中对长期影响的数据有限.
研究的目的:
- 调查幻觉观念的频率和预测因素,神奇的思维,以及在使用迷幻药后的HPPD类症状.
- 随着时间的推移,检查这些症状的变化.
- 澄清精神分裂特征和迷幻药的使用之间的关系.
主要方法:
- 未来的队列研究设计.
- 症状评估在基线,2周和4周后的迷幻体验.
- 迷幻药使用者的自然主义样本.
主要成果:
- 使用后一个月,妄想的想法减少;神奇的思维保持不变.
- 终身迷幻药的使用与基线神奇思维和妄想相关,表明相关性而不是因果关系.
- 超过30%的人在4周后报告了类似HPPD的副作用,主要是亚临床的.
- 年龄较小,女性性别,精神病史和特征吸收预测了HPPD类效应.
结论:
- 长期使用迷幻药物可能不会增加妄想或魔幻思维.
- 类似HPPD的症状很常见,但通常是亚临床的.
- 确定了HPPD类效应的风险因素,有助于风险评估.
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