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尿液TIMP2.IGFBP7反映了脏损伤后中等体积膜在患有炎的患者:一个随机对照研究
Anuchit Suksamai1, Sanpolpai Khaoprasert1, Amnart Chaiprasert2
1Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital and College of Medicine Bangkok Thailand.
概括
在肝硬化患者中,大容量体 (5L) 增加了管损伤标志物. 像TIMP-2和IGFBP-7这样的尿路生物标志物可以在此过程中预测损伤风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 生物标志物发现发现
背景情况:
- 脊柱炎的肝硬化通常需要对流体管理进行.
- 急性损伤 (AKI) 是这些患者的重大并发症.
- 在这种情况下,AKI的预测生物标志物至关重要.
研究的目的:
- 评估在经过抛物线治疗的非补偿性肝硬化患者中AKI的风险和进展情况.
- 评估尿道组织抑制金属蛋白酶-2 (TIMP2) 和胰岛素类生长因子结合蛋白7 (IGFBP7) 作为AKI预测剂的实用性.
主要方法:
- 一项随机对照试验,涉及外科医生患有不补偿性肝硬化和.
- 患者被随机分为3L和5L的体组.
- 序列尿样被分析为TIMP2和IGFBP7度在体前后.
主要成果:
- 一个5L体组显示,管损伤标记的发病率较高 (TIMP2.IGFBP7>2,TIMP2上升,TIMP2上升2/尿 Cr).
- 具体来说,5L组中的48%的TIMP2.IGFBP7>2 (p=0.015).
- 尿液TIMP2.IGFBP7/1000 (>2) 的升高显著预测了血液动力学事件 (p=0.002).
结论:
- 5L的体积与肝硬化患者的管损伤标志物增加有关.
- 尿液TIMP2和IGFBP7显示出预测AKI和血动力学事件后的生物标志物的潜力.
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