Jove
Visualize
联系我们

相关概念视频

Antigen Presenting Cells01:22

Antigen Presenting Cells

1.3K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
1.3K
Tumor Immunotherapy01:27

Tumor Immunotherapy

398
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
398
Antigen Processing Pathways01:31

Antigen Processing Pathways

771
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
771
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

332
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
332

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Immunopeptidomics-guided identification of functional neoantigens in non-small cell lung cancer.

NPJ precision oncology·2026
Same author

Comparative analysis of protein expression between oesophageal adenocarcinoma and normal adjacent tissue.

PloS one·2025
Same author

Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms.

Nature communications·2025
Same author

High proportion of PD-1 and CD39 positive CD8+ tissue resident T lymphocytes correlates with better clinical outcome in resected human oesophageal adenocarcinoma.

Cancer immunology, immunotherapy : CII·2024
Same author

Interferon-γ couples CD8<sup>+</sup> T cell avidity and differentiation during infection.

Nature communications·2023
Same author

Reactivation of low avidity tumor-specific CD8<sup>+</sup> T cells associates with immunotherapeutic efficacy of anti-PD-1.

Journal for immunotherapy of cancer·2023
Same journal

Vaccination against tumour endothelial marker Robo4 inhibits tumour growth.

Immunotherapy advances·2026
Same journal

NLRC5 expression within tumor cells is critical to activate adaptive and innate antitumor immune responses.

Immunotherapy advances·2026
Same journal

Extracellular adenosine released by mesenchymal stromal cells from young hosts boosts the antimicrobial activity of neutrophils from aged hosts against <i>Streptococcus pneumoniae</i>.

Immunotherapy advances·2026
Same journal

The resilient subset: cancer stem cells at the core of immunotherapy resistance.

Immunotherapy advances·2026
Same journal

Head-to-head comparison of nuclear imaging approaches to quantify tumor CD8<sup>+</sup> T-cell infiltration.

Immunotherapy advances·2026
Same journal

Pharmacokinetics of hyaluronidase-facilitated subcutaneous immunoglobulin 10% in pediatric patients with primary immunodeficiency disease.

Immunotherapy advances·2026
查看所有相关文章
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: May 10, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

751

在癌症中成像抗原的处理和呈现.

Doreen Lau1,2, Tim Elliott3

  • 1Centre for Inflammation Research and Translational Medicine, Department of Life Sciences, Division of Biosciences, Brunel University London, London, United Kingdom.

Immunotherapy advances
|April 23, 2025
PubMed
概括
此摘要是机器生成的。

图像学推进了我们对癌症抗原处理和呈现的理解,这对适应性免疫至关重要. 这些技术有助于监测免疫治疗和预测患者的结果.

关键词:
抗原呈现的呈现方式.处理抗原处理.生物标志物 生物标志物图像技术 图像技术 图像技术免疫疗法 免疫疗法

更多相关视频

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.0K
Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
06:05

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

6.9K

相关实验视频

Last Updated: May 10, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

751
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.0K
Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
06:05

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

6.9K

科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 生物医学成像技术 生物医学成像技术

背景情况:

  • 抗原的处理和呈现对适应性免疫和T细胞功能至关重要.
  • 这些过程的失调显著影响了癌症免疫疗法的有效性.
  • 图像技术为癌症中这些复杂的免疫事件提供了新的视角.

研究的目的:

  • 审查成像在研究抗原处理和癌症呈现中的作用.
  • 突出这些途径的成像工具和生物标志物开发的考虑因素.
  • 检查各种成像方法在临床转化中的潜力.

主要方法:

  • 文献审查侧重于成像技术及其应用于抗原处理和呈现的应用.
  • 分析关键的免疫事件,包括载荷,T细胞招募和突触形成.
  • 评估成像工具开发,生物标志物识别和临床翻译潜力.

主要成果:

  • 图像提供了对抗原处理和呈现的细胞和分子相互作用的关键见解.
  • 正在开发特定的成像工具和生物标志物来检测这些途径的组件.
  • 不同的成像方法在临床应用中展示了优势和局限性.

结论:

  • 图像是阐明癌症抗原处理和呈现机制的强大工具.
  • 从成像中获得的见解可以改善免疫疗法反应监测和治疗选择.
  • 进一步开发和验证成像技术对于临床转化和改善患者治疗结果至关重要.