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Updated: May 10, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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在CADASIL队列中血管NOTCH3聚合和疾病严重程度之间的关联 - 对NOTCH3变体特定疾病预测的影响

Minne N Cerfontaine1, Gido Gravesteijn1, Remco J Hack1

  • 1Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Annals of neurology
|April 23, 2025
PubMed
概括

皮肤血管中的NOTCH3蛋白聚合与大脑自体主导动脉病变的疾病严重程度相关,其中包括皮层下心脏病发作和白细胞大脑病变 (CADASIL). 这一发现有助于预测NOTCH3变异患者中风和痴呆风险.

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