年龄是否会影响心房的脉冲场切除过程中的安全性和有效性?
Antonio Dello Russo1,2, Claudio Tondo3, Stefano Bianchi4
1Department of Biomedical Sciences and Public Health Marche Polytechnic University Ancona Italy.
Journal of the American Heart Association
|April 23, 2025
概括
使用FARAPULSE系统进行脉冲场切除对于老年患者的心房动是安全有效的,其急性结果与年轻人相似. 虽然老年人中复发率较高,但它们与现有文献一致.
科学领域:
- 心脏病学 心脏病学
- 医疗技术 医疗技术 医学技术
- 电力生理学 电力生理学
背景情况:
- 对于老年人群中心房动 (AF) 的脉冲场移除 (PFA) 有有限的数据.
- 老年患者经常出现更高的并发症负担,需要对安全性和疗效进行评估.
研究的目的:
- 为了比较使用FARAPULSE系统的PFA在老年患者 (≥75岁) 与年轻人队伍中的安全性,疗效和结果.
- 评估经过AF切除的不同年龄组中PFA的急性和长期结果.
主要方法:
- 一项多中心研究涉及1082名通过FARAPULSE系统进行AF切除的患者.
- 患者被分为三个年龄组:<65,65-74岁和≥75岁.
- 在不同年龄层对安全性和有效性进行了比较.
主要成果:
- 老年患者 (≥75岁) 的并发症负担较高,但与年轻组相比,他们的程序指标和并发症率低 (3.0%).
- 在所有患者中都实现了肺静脉隔离.
- 平均随访时间为342天,主要疗效终点达到80.9%的患者,心律不整复发率在65岁以下患者中为14.4%,在75岁以上患者中为26.9% (P=0.011).
结论:
- 在老年患者中,FARAPULSE系统显示出安全有效的急性结局,可与年轻人相比.
- 虽然急性结果相似,但老年患者的心律失常复发率更高,与现有文献一致.
- 在不同年龄组,包括老年人中,PFA是AF切除的可行选择.
更多相关视频
相关概念视频
Disturbances in Heart Rhythm
710
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
710
Decreased pulse rate
515
Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
515
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers
1.0K
Class I antiarrhythmic drugs are used to treat various types of arrhythmias or irregular heart rhythms. These drugs block the sodium (Na+) channels in the cardiac cells, thereby affecting the movement of electrical impulses across the heart. Class I antiarrhythmic drugs are divided into three subgroups: Class IA, Class IB, and Class IC, each with distinct mechanisms of action and effects on the heart.
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
1.0K
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers
640
Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which...
640


