宿主-微生物代谢物乌尔索多西胆酸可以防止中风后的认知障碍
Xuxuan Gao1, Feng Zhang2, Jiafeng Zhang1
1Department of Neurology, Nanfang Hospital Southern Medical University Guangzhou Guangdong People's Republic of China.
Journal of the American Heart Association
|April 23, 2025
概括
乌尔索西胆酸 (UDCA) 可以预测中风后认知障碍 (PSCI) 的风险. 在中风患者中,较低的UDCA水平与PSCI相关,UDCA的使用改善了小鼠的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
背景情况:
- 脑卒中后认知障碍 (PSCI) 是中风的常见,往往被诊断不足的后果.
- 之前的研究表明,乌尔索多氧胆酸 (UDCA) 可以改善小鼠中风引起的脑损伤.
- 这项研究调查了UDCA对PSCI风险的预测价值.
研究的目的:
- 评估UDCA对中风后认知障碍 (PSCI) 风险的预测价值.
- 在急性缺血性中风患者中确定PSCI的生物标志物.
- 探索UDCA在中风和PSCI中的神经保护作用.
主要方法:
- 招募了202名轻度急性缺血性中风患者和63名大动脉狭窄患者.
- 利用机器学习开发PSCI的预测模型.
- 在小鼠中进行了动物研究,小鼠接受了中脑动脉封闭.
主要成果:
- 患有PSCI的患者表现出血UDCA水平降低和肠道微生物群改变.
- 结合UDCA,微生物群,年龄,教育和白质病变的预测模型显示出高准确度 (AUC0.904内部,0.838外部).
- 在小鼠中使用UDCA可以通过减少神经炎症和亡来改善认知功能.
结论:
- UDCA显示出作为预测PSCI风险的生物标志物的潜力.
- 在PSCI中,UDCA可能起到神经保护作用.
- 针对UDCA的早期识别和干预可以帮助预防和治疗PSCI.
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