益生菌补充对短链脂肪酸的影响:对随机对照试验的系统审查
Poliana Guiomar de Almeida Brasiel1, Sheila Cristina Potente Dutra Luquetti1
1Department of Nutrition, Federal University of Juiz de Fora, Minas Gerais 36036900, Brazil.
Nutrition reviews
|April 23, 2025
概括
益生菌补充剂可以增加短链脂肪酸 (SCFA) 水平,特别是在儿童时期. 这一系统性审查强调了益生菌对肠道健康和免疫功能的潜在益处.
科学领域:
- 微生物学和肠道健康
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 对发酵食品和益生菌的日益增长的兴趣需要了解它们对健康的影响.
- 在全球范围内,益生菌和发酵食品的消费量正在增加.
- 评估益生菌摄入的安全性和有效性至关重要.
研究的目的:
- 系统地审查益生菌补充剂对短链脂肪酸 (SCFA) 水平的影响.
- 综合来自对益生菌疗效的随机控制试验的证据.
- 通过不同的益生菌干预来评估SCFA调节.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在Medline/PubMed,Scopus,Web of Science和Embase数据库中进行了搜索.
- 包括到2024年2月发表的随机对照试验.
主要成果:
- 分析了30项涉及1499名参与者的研究,重点关注Bifidobacterium和Lactobacillus菌株.
- 53.3%的研究表明,随着益生菌补充,至少有一种SCFA的增加.
- 结果在各个子组 (健康成年人,疾病,儿童,老年人) 之间存在差异,证据确定性低至中等.
结论:
- 在童年期间补充益生菌证明了便SCFA和免疫球蛋白A (IgA) 水平的最显著增加.
- 中等到高确定性证据支持益生菌对儿童的益处.
- 进一步的研究可能会澄清各种人群的最佳益生菌菌株和剂量.
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