慢性鼻炎与鼻和嗅觉功能障碍:比较嗅觉训练和葡萄糖皮质体治疗
Zhiqiang Zhang1,2,3, Junhao Tu1, Binxiang Tang1
1Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
The Laryngoscope
|April 23, 2025
概括
葡萄糖皮质类药物 (GC) 与嗅觉训练 (OT) 结合,改善了慢性鼻炎患者的嗅觉功能. 这种组合疗法特别有效地减少了带有鼻的异性慢性鼻炎的嗅觉波动.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 鼻科 鼻科是指鼻科的专家.
- 过敏和免疫学 过敏和免疫学
背景情况:
- 带有鼻息肉的慢性鼻炎 (CRSwNP) 通常伴有嗅觉功能障碍 (OD).
- 在CRSwNP表型中,嗅觉训练 (OT) 和糖皮质类药物 (GC) 具有OD的有限的比较数据.
研究的目的:
- 为了评估GC和OT对臭味功能障碍 (OD) 的比较有效性,在患有带鼻息肉的慢性鼻炎 (ECRSwNP) 和非带鼻息肉的慢性鼻炎 (NonECRSwNP) 的患者中.
主要方法:
- 手术后患有OD的患者被随机分配到GC,OT或联合GC和OT (GCwOT).
- 现型分层是基于组织中异氨基的百分比 (>10%对于ECRSwNP).
- 嗅觉功能 (TDIS),生活质量 (SNOT-22),内镜评分 (LKES) 和嗅觉波动 (OF) 在1,3个月和6个月被评估.
主要成果:
- 随着时间的推移,GC和OT都改善了SNOT-22和LKES.
- 与单独使用GC或OT相比,GCwOT在1个月后显示出优异的TDIS改善.
- 在3个月和6个月的ECRSwNP患者中,GCwOT显示了持续的TDIS改善和减少的OF.
结论:
- 结合GC和OT治疗有效地提高了CRSwNP患者的嗅觉功能.
- GCwOT显著降低了嗅觉波动,特别是在ECRSwNP表型中.
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