对高温敏感的DEAR4凝结通过在Arabidopsis核中招募TOPLESS来赋予耐热性
Qi Wang1, Zhen Gong1, Ziqiang Zhu1,2
1College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.
The Plant journal : for cell and molecular biology
|April 23, 2025
概括
转录因子DEAR4通过在高温下形成核凝结物来增强植物的耐热性. 这种机制涉及招募TOPLESS来抑制基因,最终促进热冲击蛋白质的产生,以改善热耐受性.
科学领域:
- 植物生物学 植物生物学
- 分子机制的分子机制
- 无生物应激反应应激反应
背景情况:
- 全球变暖对全世界的作物产量构成重大威胁.
- 了解植物对高温的感知和信号,对于农业的弹性至关重要.
- 植物耐热性背后的分子机制尚未完全阐明.
研究的目的:
- 研究转录因子DEAR4在植物耐热性中的作用.
- 阐明DEAR4赋予热耐性的分子机制.
- 探索DEAR4在提高作物耐热性方面的潜力.
主要方法:
- 使用Arabidopsis thaliana研究了转录因子DEAR4在耐热性中的功能.
- 观察到高温诱导的液体液相分离 (LLPS) 和DEAR4.的核凝结物形成.
- 分析了DEAR4-TOPLESS的相互作用及其对基因脱乙和基因表达的影响.
- 进行了全基因组的转录分析,以确定DEAR4受调节的基因,包括热冲击蛋白 (HSP).
主要成果:
- 转录因子DEAR4积极调节Arabidopsis中的耐热性.
- 高温导致DEAR4经历液体液相分离 (LLPS) 并形成核凝结物.
- 亲爱的4-TOPLESS联合凝结剂通过调节GASA5的基因组脱甲基化,这是HSPs的负调节剂,从而增强转录抑制.
- DEAR4诱导多个热冲击蛋白 (HSP) 的表达,有助于热耐受性.
结论:
- DEAR4使用LLPS来调解转录抑制,从而赋予植物耐热性.
- 这项研究揭示了植物热应激反应的新机制.
- 这些发现为制定提高作物耐热性的策略提供了基础.
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