虫通过部署先天免疫的抗微生物程序来重塑宿主肠道微生物群和免疫调节
Yang Zou1,2, Lixia Pu1,2, Aijiang Guo1,2
1State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Gut microbes
|April 23, 2025
概括
虫通过激活天生的免疫力来操纵肠道微生物群,促进有益的Lactobacillus细菌并抑制有害的微生物. 这种机制受到维生素D的影响,有助于寄生虫的生存,可以作为治疗的目标.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 寄生虫学的寄生虫学
背景情况:
- 虫通常会改变宿主肠道微生物群,扩大乳杆菌种群,从而影响宿主免疫调节.
- 虫操纵肠道微生物群和宿主免疫力的精确机制在很大程度上是未知的.
研究的目的:
- 阐明虫操纵肠道微生物群和宿主免疫调节的机制.
- 确定参与虫诱导的肠道失调和免疫抑制的关键分子和途径.
主要方法:
- 使用了幼虫 Echinococcus multilocularis 感染模型,与其他虫感染进行了验证.
- 采用多方面的技术,包括体外细胞培养和体外食干预.
- 研究了与cathelicidin相关的抗微生物 (CRAMP) 和通用类似受体信号的作用.
主要成果:
- 虫利用先天免疫力,特别是来自巨细胞的CRAMP,促进乳酸菌并抑制阴性细菌.
- 虫分泌产品促进TLR信号传递,这种信号可以通过食维生素D来调节.
- 这种由天生的免疫驱动的微生物组编辑增强了Treg细胞扩张,寄生虫生存和感染结果.
结论:
- 虫利用宿主天生的免疫力重塑肠道微生物群,促进有利于寄生虫生存和免疫逃避的环境.
- 饮食维生素D可以调节这种虫诱导的免疫反应.
- 针对这种天生的免疫-微生物组轴,为虫感染提供了潜在的治疗策略.
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