持续免疫持久性 完成四剂量sIPV疫苗接种后的五年
Chu Kai1, Li Yurong2, Liu Sheng3
1Institute of Clinical Evaluation of Vaccines, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Vaccines
|April 23, 2025
概括
萨宾菌株无活化脊髓灰质炎疫苗 (sIPV) 在接种疫苗后五年表现出强大的长期免疫持久性. 中和抗体几何平均标位仍然很高,这表明目前可能不需要强剂.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 之前的研究评估了萨宾菌株无活化脊髓灰质炎疫苗 (sIPV) 在四年内的免疫耐用性.
- 需要对sIPV免疫反应的长期持久性进行更新.
研究的目的:
- 评估萨宾菌株无活化脊髓灰质炎疫苗 (sIPV) 的长期免疫持久性.
- 为了比较sIPV的免疫持久性与儿童的萨尔克菌株无活化脊髓灰质炎疫苗 (wIPV).
主要方法:
- 第四期,开放标签,并行控制的观察性研究,涉及6.5岁儿童.
- 参与者在2,3,4个月和18个月后接受了四次sIPV或wIPV剂量.
- 采集血液样本进行脊髓灰质炎中和抗体 (nAb) 测试,以确定免疫持久性的非劣势性.
主要成果:
- 在6.5年后,针对1~3型脊髓灰质炎病毒的nAbs的血清阳性率在sIPV组超过99%,在wIPV组超过98%.
- 对于nAbs的几何平均标位 (GMT) 在sIPV组显著高于所有三种血清型的wIPV组.
- 与wIPV相比,sIPV的nAb血清阳性率和GMT的非劣势性在所有血清型中得到证实.
结论:
- 在接种四剂疫苗后的5年内,sIPV保持良好的免疫性持久性.
- 中和抗体GMT保持在血清保护值以上,表明持续免疫力.
- 基于观察到的免疫持久性,目前可能不需要对sIPV进行强剂.
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