累积生命的基本8分数和心血管疾病风险
James Walker1, Daniel Won1, James Guo1
1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
从年轻成人到中年,保持良好的心血管健康 (CVH) 显著降低了患心血管疾病 (CVD) 和晚年死亡的风险. 随着时间的推移,CVH的改善也与更好的长期心血管结果有关.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 大多数关于心血管健康 (CVH) 和疾病风险的研究都使用单个时间点测量.
- 了解累积CVH的长期影响对于有效的早期预防策略至关重要.
研究的目的:
- 评估从18岁到45岁的美国心脏协会生命基本8 (LE8) 评分测量的累积心血管健康 (CVH) 与发生心血管疾病 (CVD) 和中年死亡率的风险之间的关联.
主要方法:
- 年轻成年人冠状动脉风险发展研究 (CARDIA) 从1985年到2020年跟踪了4832名参与者.
- 多变量考克斯比例危险模型分析了累积的LE8得分 (曲线下的面积),LE8得分在45岁时,LE8得分斜率 (改善) 针对CVD事件和45岁后的死亡率.
主要成果:
- 18至45岁的累计LE8得分 (更好的CVH) 较高,与45岁以后心血管疾病和死亡率的风险较低显著相关.
- 在45岁时,累积的CVH和CVH都与降低心血管疾病风险独立相关.
- 年轻成年期LE8分数的改善趋势 (正倾) 也预测了未来心血管疾病风险的降低.
结论:
- 在整个成年期保持和改善心血管健康对于长期预防心血管疾病至关重要.
- 累积的CVH,中年CVH和随着时间的推移而改善的CVH都与中年心血管疾病风险的降低有关.
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