抗微生物耐药性和基因组洞察Enterococcus faecalis从印度旁遮普邦的肉和他们的处理者中分离出来的
Neha Parmar1, Randhir Singh1, Anuj Tyagi2
1Department of Veterinary Public Health and Epidemiology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
Foodborne pathogens and disease
|April 23, 2025
概括
对多种药物耐药的Enterococcus faecalis在印度的肉养殖场和处理者中被发现. 这突出了家禽作为耐药细菌的储存库,需要进一步研究传播动态.
科学领域:
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
- 公共卫生 公共卫生
背景情况:
- 肠杆菌 (Enterococcus faecalis) 是一种常见的肠道细菌,也是由于抗菌素耐药性 (AMR) 的病原体不断增长的病原体.
- 家禽养殖场可以作为耐药细菌的储存库,对动物和人类健康构成风险.
研究的目的:
- 调查来自印度肉养殖场的E. faecalis的AMR概况,毒性因子和遗传多样性.
- 探索家禽和农场处理者之间的潜在传播动态.
主要方法:
- 从肉排泄物和处理者拭子中分离和识别E. faecalis.
- 全基因组测序 (WGS) 用于识别抗菌素耐药性基因 (ARG) 和毒性因子.
- 序列类型,以确定遗传关系和潜在的传播.
主要成果:
- E. faecalis从47%的便和26.47%的处理者拭子中分离出来;没有人体便的分离物.
- 对红红素,四环素,西普罗弗洛克萨,菌素和线索利德观察到高耐药性;83.49%的隔离物显示多药性耐药性 (MDR).
- WGS确定了许多ARG和毒性因子;ST-7317在家禽和处理者隔离物中都很常见,这表明潜在的传播.
结论:
- 禽类环境是多药耐药E. faecalis. 的储库.
- 在家禽和处理者之间存在潜在的传播,尽管方向性不清楚.
- 需要扩大监测和分子研究,以了解传播和减轻公共卫生风险.
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