带长度和神经发育障碍,国家队列研究
Cathrine Ebbing1,2, Anne Halmoy3,4, Svein Rasmussen1
1Department of Clinical Science, University of Bergen, Bergen, Norway.
PloS one
|April 23, 2025
概括
带长度与神经发育障碍 (NDD) 有关. 短绳和长绳都与ADHD,ID和CP等疾病有关,这表明它们有共同的发育途径.
科学领域:
- 围产期健康 围产期健康
- 神经发育障碍 神经发育障碍
- 生殖生物学 生殖生物学
背景情况:
- 胎儿生命逆境是神经发育障碍 (NDD) 的确立危险因素.
- 带在胎儿发育中的作用至关重要,但它与后来的NDD的关联仍未得到充分研究.
- 了解胎儿发育标志物可能会为NDD的病因提供见解.
研究的目的:
- 调查带长度与各种NDD之间的关联,包括ADHD,ASD,ID,CP,,视力或听力受损.
- 为了确定这些关联是否根据孩子的性别有所不同.
- 提供基于人口的证据,证明带特征与神经发育结果之间的关系.
主要方法:
- 在挪威 (1999-2019) 进行了一项基于人口的前性队列研究,其中包括超过85万只活生生的独生子.
- 挪威医疗出生登记处和国家卫生登记处之间的数据链接确定了暴露 (极端带长度:<第5个或≥95个百分点) 和结果 (NDD).
- 使用后勤回归分析来评估绳子长度和NDD之间的关联,按性别分层.
主要成果:
- 极端的带长度与858,397个出生的大队伍中的几个NDD有关.
- 长带与ADHD风险 (OR 1.15) 有积极的关联.
- 短带与智力障碍 (OR2.42),听力障碍 (OR1.41) 和 (OR1.31) 的风险增加有关. 大脑麻 (CP) 与短和长的绳索有关.
- 在带长度和视力受损之间没有发现显著的关联.
结论:
- 这项研究表明,带长度与发展神经发育障碍的风险之间存在显著的关联.
- 这些发现表明,带的发育和神经发育可能具有共同的生物学途径.
- 带长度可以被认为是神经发育结果的潜在生物标志物.
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