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一个分子定义的mPFC-BLA电路专门调节社会新奇的偏好

Yiqiong Liu^1,2,3, Ying Wang^1,2,3, Guoguang Xie^1,2,3

¹Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA.

Science advances

|April 23, 2025

概括

研究人员确定了一个特定的大脑电路调节社会新奇的偏好. 激活这些神经元会影响人们对新的社会互动的偏好,揭示了社会行为的关键机制.

科学领域:

神经科学是一个神经科学.
行为科学行为科学
遗传学是一个遗传学.

背景情况:

社会新奇的偏好对于生存至关重要,有助于威胁和机会评估.
在社会新奇事物偏好背后的特定神经机制仍然在很大程度上是未知的.
全基因组关联研究将Il1rapl2与社会缺陷障碍联系起来.

研究的目的:

为了识别分子定义的神经元亚型和电路调节社会新奇的偏好.
调查前额叶皮质 (mPFC) 中表达神经元在社会行为中的作用.

主要方法:

使用Il1rapl2创建鼠标线来进行有针对性的操纵.
采用化学遗传学来激活表达mPFC的神经元.
使用纤维光度用于体内神经活动记录和用于电路映射的病毒追踪.

主要成果:

化学遗传激活mPFCIl1rapl2⁺神经元显著损害了社会新奇的偏好.
这种操纵对一般社交能力的影响最小.
从mPFC投射到底侧杏仁体 (BLA) 的神经元被确定为关键介质.

结论:

一个特定的mPFC-BLA电路,涉及表达神经元,精确地调节社会新奇的偏好.
这项研究强调了分子定义的神经元亚型在不同的社会行为中的重要性.
这些发现为与Il1rapl2相关的社会缺陷障碍提供了潜在的神经基础.

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