遗传和环境对与年龄相关的听力损失的贡献:长线双胞胎研究的结果
Ryan M O'Leary1, Arthur Wingfield1, Michael J Lyons2
1Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts, USA.
Trends in hearing
|April 23, 2025
概括
遗传因素在整个衰老过程中显著影响听力敏度,其贡献在12年内保持稳定. 然而,环境因素会随着时间的推移导致听力发生变化.
科学领域:
- 听力学 听力学是指听力学.
- 遗传学 遗传学 是一个
- 老年学是一门学科.
背景情况:
- 在全球范围内,残疾性听力损失影响了4.3亿多人,随着年龄的增长而增加.
- 遗传对听力损失的贡献已知,但它们的时间变化不太了解.
研究的目的:
- 调查遗传和环境对听力敏度随时间推移的贡献.
- 分析不同频率和年龄段对听力遗传影响的变化.
主要方法:
- 利用来自越南时代双胞胎老龄化研究 (VETSA) 的数据,包括超过1000对男性双胞胎 (单胞胎和双胞胎).
- 在三个波段 (平均年龄为56岁,62岁,68岁) 中,评估了跨多个频率 (500-8000赫兹) 的纯音听力值.
- 采用基因信息结构方程模型来确定遗传和环境影响.
主要成果:
- 遗传因素占所有频率和时间点的听力敏度变异的49.4%67.7%.
- 遗传和环境对听力敏度的贡献的比例在12年内和跨频率保持一致.
- 听力敏度的稳定性主要归因于遗传因素,而变化与独特的环境因素有关.
结论:
- 晚年生活中的听力敏度在很大程度上是由遗传因素决定的.
- 归因于遗传学的听力敏度的比例在12年内保持稳定.
- 环境因素在随着时间的推移观察到的听力敏度变化中起着关键作用.
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