消化道全局症状严重程度的验证作为患者报告的回流症状评估结果
Walter W Chan1, Matthew Schroeder2, Allyson Richardson1
1Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
The American journal of gastroenterology
|April 23, 2025
概括
用视觉模拟尺度 (VAS) 测量的全球症状严重程度 (GSS) 有效地评估反流症状负担和治疗结果. 在治疗前和治疗后,GSS是评估胃食道逆流症 (GERD) 的一个有价值的工具.
科学领域:
- 胃肠病学 胃肠病学
- 临床试验 临床试验
- 患者报告的结果
背景情况:
- 视觉模拟尺度 (VAS) 提供了一种简单,患者友好的方法来评估症状,需要最小的翻译.
- 使用VAS评估食道全局症状严重程度 (GSS) 对于理解初始反流症状负担至关重要.
- 与已建立的问卷和客观措施进行比较是验证GSS实用性的关键.
研究的目的:
- 通过VAS测量食道全局症状严重程度 (GSS) 的值.
- 将GSS与其他验证的问卷和客观反流指标进行比较.
- 确定GSS在评估反流管理后的结果中的实用性.
主要方法:
- 汇集了来自北美,欧洲和亚洲1296名接受pH阻抗测试的患者的数据.
- 单变量,多变量和ROC分析将GSS与GERDQ,GERD-HRQL,RSI和pH阻抗指标 (里昂共识2.0) 相比较.
主要成果:
- GSS与GERDQ,GERD-HRQL,RSI,酸暴露时间和总反流发作有显著的相关性 (P < 0.0001).
- 在异常的GERDQ,GERD-HRQL,RSI,病态酸暴露时间和确定的GERD中观察到更高的GSS得分.
- 在预测异常反流指标方面,GSS表现出与其他问卷表相比的非劣势,并且对治疗变化敏感.
结论:
- 食道全局症状严重程度 (GSS) 与验证的反流问卷相关,并区分异常的反流负担.
- GSS的变化有效地反映了治疗结果和患者对GERD管理的满意度.
- GSS 作为一个有价值的工具,用于评估治疗前后出现反流症状的患者.
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