为临床试验制定一个核心结果集,针对旨在改善老年人遵守适当多药的干预措施 - - 一项国际共识研究
Hanadi Al Shaker1,2, Heather Barry3, Carmel Hughes1
1School of Pharmacy, Queen's University Belfast, Belfast, United Kingdom.
Age and ageing
|April 23, 2025
概括
这项研究开发了一个核心结果集 (COS),以标准化改善多药老年人药物坚持的研究. 该COS包括六个关键结果,用于一致的试验评估.
科学领域:
- 老年学是指老年学的学科.
- 临床药房 临床药房
- 医疗保健服务研究 医疗服务研究
背景情况:
- 药物不服药是多药性老年人的一个重要问题.
- 现有的干预措施显示不一致的结果,阻碍了直接比较.
- 要有效评估干预措施,需要采用标准化的方法.
研究的目的:
- 开发一个核心结果集 (COS) 试验的重点是改善药物坚持在老年人多药.
- 建立对这一群体研究的关键结果的共识.
主要方法:
- 一项涉及多方利益相关者 (学术界,医疗保健专家,公众) 的德尔菲研究评估了13个潜在结果.
- 使用九分利克尔特等级来评估结果的重要性.
- 在线名义组技术 (NGT) 会议对共识的结果进行了改进和投票.
主要成果:
- 六个结果达成共识,被纳入COS.
- 这些包括药物坚持,治疗负担,HRQoL,医疗利用率,AE/SE和成本效益.
- 需要共识 ≥80%的关键评级和≤15%的不重要的评级.
结论:
- 开发的COS提供了一个标准化的框架,用于对老年人多药服药的干预研究.
- 这将使研究结果更加一致和可比.
- 未来的研究应该集中在确定适合COS结果的测量工具上.
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