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随时间推移分析了ABG0050类偏微生物对 brojlers肠道免疫系统的影响
Hiroya Kondo1, Shiori Iino2, Takako Fukuda2
1Bioscience Research Laboratory, Sumitomo Chemical Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-8558, Japan; Graduate School of Integrated Sciences for Life, 2 1-3-2 Kagamiyama, Higashi-Hiroshima 739-8528, Japan.
Poultry science
|April 23, 2025
概括
像Lactiplantibacillus plantarum ABG0050这样的偏微生物可以作为肉生产中的抗生素替代品. 这项研究发现ABG0050积极调节肉的先天和适应性免疫系统,影响免疫标记物和体重增加.
科学领域:
- 动物科学动物科学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 在肉生产中使用抗生素面临着越来越多的监管审查.
- 偏微生物,即无活化的微生物细胞,为提高家禽健康提供了潜在的替代方案.
- 乳植物菌植物体ABG0050是一种特定的偏微生物,其免疫调节作用受到研究.
研究的目的:
- 为了评估持续摄入Lactiplantibacillus plantarum ABG0050对肉免疫力的影响.
- 评估免疫系统在恒温状态和对免疫刺激 (LPS) 的反应中的变化.
- 为了将免疫标志物表达与生长参数 (如体重增加) 相关联.
主要方法:
- 肉幼从3到21天的年龄被食基本饮食或基本饮食补充了0.01%的偏微生物ABG0050.
- 收集了便样本,以分析免疫标记物随时间变化的变化.
- 鸟类在21日接受了脂聚糖 (LPS) 的挑战,并采集了腹腔组织以进行免疫因子分析.
主要成果:
- 偏微生物ABG0050显著改变了中的抗微生物 (鸟类β-defensin 7和12) 的表达,表明先天免疫调节.
- 不断摄入ABG0050导致T1型细胞因子 (IFN-γ,IL-6,IL-12) 在前腔组织显著增加,而不管LPS刺激.
- 免疫标记物变化与体重增加有关,这表明免疫和生长之间存在联系.
结论:
- 寄生菌Lactiplantibacillus plantarum ABG0050有效调节肉的先天性和适应性免疫反应.
- ABG0050促进了转向Th1免疫主导的转变,独立于免疫挑战.
- ABG0050的免疫调节作用与肉生长性能有关,强调其作为抗生素替代品的潜力.
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