聚乙烯微塑料通过肠道微生物群诱导的肝脂肪酸代谢功能障碍损害了的生长
Jiaping Xu1, Qiuyue Zhang1, Yu Wang1
1MOE Key Laboratory on Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
Journal of hazardous materials
|April 23, 2025
概括
携带甲酸 (PAE) 的聚乙烯微塑料 (MPs) 损害了的生长和肝脏健康. 国会议员充当"特洛伊木马",通过肠肝相互作用恶化毒性,改变肠道微生物群.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 动物科学动物科学
背景情况:
- 微塑料 (MPs) 对陆地动物构成风险,但它们对 (Gallus gallus domesticus) () 的影响尚未得到充分研究.
- 在生态和农业上具有重要意义,将人类和环境健康联系起来.
研究的目的:
- 调查聚乙烯 (PE) MPs和甲酸 (PAE) 对生长,肝脏代谢和肠道微生物群的影响.
- 阐明MP和PAE的联合毒性作用,以及肠肝轴的作用.
主要方法:
- 利用多omics和16S rRNA测序来分析的反应.
- 暴露清洁PE MPs和PE MPs上加了PAE.
主要成果:
- 患有PAE的PE MP显著减少了体重增加 (高达71.2%) 和肝脏甘油三水平 (高达50.1%).
- 增高PAE的MPs破坏了脂肪酸代谢,降低了关键基因 (FAN,SCD,ELOVL5) 的调节,并诱发了肝炎.
- 暴露改变了肠道微生物群,增加了Firmicutes/Bacteroidetes的比率,并影响了Actinobacteriota和Proteobacteria.
结论:
- 国会议员作为PAE的"特洛伊木马",通过肠肝轴相互作用放大毒性.
- 肠道微生物群在中介肝功能障碍和MP和PAE暴露引起的生长障碍方面发挥着至关重要的作用.
- 研究结果强调了协同作用的毒性,以及考虑农业物种中污染物的综合影响的重要性.
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