大脑网络连接是前兆性莱维体型痴呆症中潜在的神经精神症状的基础
Laura M Wright1, Paul C Donaghy1, David J Burn1
1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; NIHR Newcastle Biomedical Research Centre, UK.
Neurobiology of aging
|April 23, 2025
概括
在帕金森病中出现神经心理症状.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 神经精神症状 (NPS) 在莱维体痴呆症 (LBD) 中很常见,并且与更糟糕的结果有关.
- NPS可能源于受LBD影响的大脑网络中断.
- 了解NPS的神经基础对于开发向治疗至关重要.
研究的目的:
- 通过静止状态的功能性核磁共振 (MRI) 来研究前进性LBD中NPS的神经相关物.
- 检查特定的NPS (情绪障碍,精神病,焦虑) 与轻度认知障碍 (MCI-LB) 和轻度认知障碍 (PD-MCI) 的帕金森病中的大脑网络连接之间的关联.
主要方法:
- 57名参与者 (28名MCI-LB,29名PD-MCI) 接受了休息状态的功能性MRI.
- 在五个静止状态网络中评估了连接性:主要视觉,背部注意,突出,边缘和默认模式网络.
- 使用神经精神病 inventory 测量神经精神病症状,并通过主要成分分析进行分析.
主要成果:
- 在PD-MCI中,情绪症状和焦虑与边缘网络,默认模式和突出网络的连接性发生变化相关.
- 在PD-MCI中,精神病的严重程度与网络连接有广泛的相关性.
- 在MCI-LB中没有发现显著的NPS连接相关性,尽管观察到焦虑和中间前额连接的趋势.
结论:
- 改变的大脑网络连接,特别是在与情绪调节相关的网络内,可能是PD-MCI中情绪和焦虑症状的基础.
- 在MCI-LB中NPS的神经支需要在更大,更多样化的LBD队列中进一步调查.
- 识别神经相关性对开发有效的LBD症状治疗至关重要.
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