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Updated: Apr 29, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

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基于寡类载体的CGA-N9衍生的计算机辅助设计及其抗真菌评估

Fu Yan1, Yiqing Sun1, Shaojie Zhang1

  • 1Zhengzhou Key Laboratory of Functional Molecules for Biomedical Research, Henan University of Technology, 450001 Zhengzhou, Henan, PR China; School of Biological Engineering, Henan University of Technology, 450001 Zhengzhou, Henan, PR China.

Bioorganic chemistry
|April 23, 2025
PubMed
概括

计算机辅助设计增强了抗真菌CGA-N9,创造了CGAN93. 这种显示出改善的运输,强烈的活性对候选菌种,和优越的安全性,提供了一个有希望的新治疗候选菌病.

关键词:
抗微生物活性的抗菌活性.抗微生物是一种抗微生物.在Candida tropicalis的寡转运器中.药物设计 药物设计分子对接是分子对接.

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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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